MATERIAL SAFETY DATA SHEET
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SAFETY DATA SHEET according to EC Directive 2001/58/EC
2,4-Pentandione; Pentane-2,4-dione; Acetyl acetone.
1. Product Identification
CAS No.: 123-54-6
Molecular Weight: 100.11
Chemical Formula: CH3COCH2COCH3
Product Codes: S926, S985
2. Composition/Information on Ingredients
Chemical nature
Pentane-2,4-dione
Hazardous components
Chemical Name Pentane-2,4-dione
CAS-No. 123-54-6
EINECS-No. / EC-No. 204-634-0
Symbol(s) Xn
R-phrase(s) R-10, R-22
Concentration (%) 99-100
3. Hazards Identification
Emergency Overview
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Risk advice to man and the environment
Flammable
Harmful if swallowed
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Flammability Rating: 2 - Moderate
Reactivity Rating: 1 - Slight
Contact Rating: 2 - Moderate
Lab Protective Equip: GOGGLES; LAB COAT; VENT HOOD; PROPER GLOVES; CLASS B EXTINGUISHER
Storage Color Code: Red (Flammable)
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Potential Health Effects
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2,4-Pentanedione produces a clinically, anatomically, and morphologically distinct neurotoxic response which differs from that produced by the other ketones. (Patty, et al)
Inhalation: Inhalation of vapors produces a narcotic effect. Symptoms of exposure may include drowsiness and irritation of the respiratory passages. Greater exposure may cause headache, dizziness, nausea, vomiting, and loss of consciousness.
Ingestion: Symptoms may include irritation to the gastrointestinal tract and other symptoms paralleling inhalation exposure. May produce irreversible neurological impairment and possibly death.
Skin Contact: Causes irritation. May be absorbed through the intact skin in harmful amounts.
Eye Contact: Vapors are irritating to the eyes. Splashes are severely irritating with pain, redness.
Chronic Exposure: Repeated exposure to low concentrations may be cumulative.
Aggravation of Pre-existing Conditions: Persons with pre-existing neurological disorders may be more susceptible to the effects of the substance.
4. First Aid Measures
Inhalation: Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Call a physician.
Ingestion: Give large amounts of water to drink. Never give anything by mouth to an unconscious person. Get medical attention.
Skin Contact: Remove any contaminated clothing. Wash skin with soap or mild detergent and water for at least 15 minutes. Wash clothes before reuse. Get medical attention if irritation develops or persists.
Eye Contact: Immediately flush eyes with plenty of water for at least 15 minutes, lifting lower and upper eyelids occasionally. Get medical attention immediately.
5. Fire Fighting Measures
Fire:
Flash point: 34C (93F) CC
Autoignition temperature: 335C (635F)
Flammable limits in air % by volume:
lel: 2.4; uel: 11.6
Flammable Liquid and Vapor!
Explosion: Above flash point, vapor-air mixtures are explosive within flammable limits noted above. Vapors can flow along surfaces to distant ignition source and flash back. Sensitive to static discharge.
Fire Extinguishing Media: Dry chemical, alcohol foam or carbon dioxide. Water spray may be used to keep fire exposed containers cool.
Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full face piece operated in the pressure demand or other positive pressure mode. This highly flammable liquid must be kept from sparks, open flame, hot surfaces, and all sources of heat and ignition.
6. Accidental Release Measures
Ventilate area of leak or spill. Remove all sources of ignition. Wear appropriate personal protective equipment as specified in Section 8. Isolate hazard area. Keep unnecessary and unprotected personnel from entering. Contain and recover liquid when possible. Use non-sparking tools and equipment. Collect liquid in an appropriate container or absorb with an inert material (e. g., vermiculite, dry sand, earth), and place in a chemical waste container. Do not use combustible materials, such as saw dust. Do not flush to sewer! If a leak or spill has not ignited, use water spray to disperse the vapors, to protect personnel attempting to stop leak, and to flush spills away from exposures.
7. Handling and Storage
Protect against physical damage. Store in a cool, dry well-ventilated location, away from any area where the fire hazard may be acute. Outside or detached storage is preferred. Separate from incompatibles. Containers should be bonded and grounded for transfers to avoid static sparks. Storage and use areas should be No Smoking areas. Use non-sparking type tools and equipment, including explosion proof ventilation. Containers of this material may be hazardous when empty since they retain product residues (vapors, liquid); observe all warnings and precautions listed for the product.
8. Exposure Controls/Personal Protection
Airborne Exposure Limits: None established.
Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area.
Personal Respirators (NIOSH Approved):
For conditions of use where exposure to the substance is apparent, consult an industrial hygienist. For emergencies, or instances where the exposure levels are not known, use a full-facepiece positive-pressure, air-supplied respirator. WARNING: Air purifying respirators do not protect workers in oxygen-deficient atmospheres.
Skin Protection: Rubber or neoprene gloves and additional protection including impervious boots, apron, or coveralls, as needed in areas of unusual exposure.
Eye Protection: Use chemical safety goggles and/or a full face shield where splashing is possible. Maintain eye wash fountain and quick-drench facilities in work area.
9. Physical and Chemical Properties
Appearance: Colorless to yellowish liquid.
Odor: Pleasant odor.
Solubility: Soluble in water, 12% w/w
Density: 0.972 @20/20C (68F)
pH: No information found.
% Volatiles by volume @ 21C (70F): 100
Boiling Point: 140C (284F)
Melting Point: -23C (-9F)
Vapor Density (Air=1): 3.5
Vapor Pressure (mm Hg): 7.0 @ 20C (68F)
Evaporation Rate (BuAc=1): No information found.
10. Stability and Reactivity
Stability: Stable under ordinary conditions of use and storage.
Hazardous Decomposition Products: Carbon dioxide and carbon monoxide may form when heated to decomposition.
Hazardous Polymerization: Will not occur.
Incompatibilities: Oxidizing agents, zinc, copper, nickel and related alloys.
Conditions to Avoid: Heat, flame, ignition sources, air, light and incompatibles.
11. Toxicological Information
Oral rat LD50: 55 mg/kg; skin rabbit LD50: 810 mg/kg; Irritation skin rabbit 488 mg open: mildly irritating; irritation eye rabbit 20 mg: severely irritating; inhalation rat LCLo: 1000 ppm/4H; investigated as a mutagen, reproductive effector.
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---NTP Carcinogen---
Ingredient Known Anticipated IARC Category
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2,4-Pentanedione (123-54-6) No No None
12. Ecological Information
Environmental Fate:
When released into the soil, this material may biodegrade to a moderate extent. When released into the soil, this material is expected to leach into groundwater. When released into the soil, this material is expected to quickly evaporate. When released into water, this material may biodegrade to a moderate extent. This material has a log octanol-water partition coefficient of less than 3.0. This material is not expected to significantly bioaccumulate. When released into the air, this material may be moderately degraded by reaction with photochemically produced hydroxyl radicals. When released into the air, this material is expected to be readily removed from the atmosphere by wet deposition. When released into air, this material is expected to have a half-life between 10 and 30 days.
Environmental Toxicity:
No information found.
13. Disposal Considerations
Whatever cannot be saved for recovery or recycling should be handled as hazardous waste and sent to a RCRA approved incinerator or disposed in a RCRA approved waste facility. Processing, use or contamination of this product may change the waste management options. State and local disposal regulations may differ from federal disposal regulations. Dispose of container and unused contents in accordance with federal, state and local requirements.
14. Transport Information
ADR/RID/ADNR
UN-No 2310
Class 3
Packaging group III
Description of the goods
PENTANE-2,4-DIONE
IMDG
UN-No 2310
Class 3
Packaging group III
Description of the goods
PENTANE-2,4-DIONE
Marine Pollutant: No
EmS:
IATA
UN-No 2310
Class 3
Packaging group III
Description of the goods
PENTANE-2,4-DIONE
15. Regulatory Information
- Labeling according to EEC Directive
Hazardous components which must be listed on the label: Pentane-2,4-dione
Symbol(s)
Xn Harmful
R-phrase(s)
R10
Flammable
R22
Harmful if swallowed
S-phrase(s)
S21
When using do not smoke
S23
Do not breathe vapour
S24/25
Avoid contact with skin and eyes

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HUZHOU XINAOTE（HAIPU） PHARMACEUTICAL & CHEMICAL CO.,LTD. provides the information contained herein in good faith but makes no representation as to its comprehensiveness or accuracy. This document is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. Individuals receiving the information must exercise their independent judgment in determining its appropriateness for a particular purpose. HUZHOU XINAOTE（HAIPU） PHARMACEUTICAL & CHEMICAL CO.,LTD. MAKES NO REPRESENTATIONS OR WARRANTIES, EITHER EXPRESS OR IMPLIED, INCLUDING WITHOUT LIMITATION ANY WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE WITH RESPECT TO THE INFORMATION SET FORTH HEREIN OR THE PRODUCT TO WHICH THE INFORMATION REFERS. ACCORDINGLY, MALLINCKRODT BAKER, INC. WILL NOT BE RESPONSIBLE FOR DAMAGES RESULTING FROM USE OF OR RELIANCE UPON THIS INFORMATION.
****************************************************Prepared by: Environmental Health & Safety